Ellis Genge will start in the front row for England in their opening Test against Argentina in San Juan on Saturday.
The Leicester Tigers prop, named Young Player of the Year and Newcomer of the Year by supporters at the end of his first full season at the club, wins his second cap at loosehead prop.
George Ford, who rejoins Leicester this summer, is at fly-half and is one of the vice-captains in a team led by Dylan Hartley.
England head coach Eddie Jones gives international debuts to Tom Curry, Alex Lozowski, Harry Williams and Mark Wilson, with seven more uncapped players on the bench.
Hartley wins his 85th cap and will move ahead of former captain Martin Johnson and alongside Rory Underwood and Lawrence Dallaglio as the third-most-capped England player of all time.
“I have selected a group of experienced players across the spine of this team as well as four young players who will be eager to go out and play well on their debuts for England,” said Jones.
“I have been impressed with the way the whole squad has trained and gelled together in a short amount of time. They all realise the opportunity that they have to be involved in this England side and I’m sure they will show that commitment on Saturday.
Saturday’s match is shown live on BBC2, kick-off is at 8.15pm UK time.
England (v Argentina)
15 Mike Brown (Harlequins, 60 caps)(vice-captain)
14 Marland Yarde (Harlequins, 11 caps)
13 Henry Slade (Exeter Chiefs, 5 caps)
12 Alex Lozowski (Saracens, uncapped)
11 Jonny May (Gloucester Rugby, 25 caps)
10 George Ford (Bath Rugby, 35 caps)(vice-captain)
9 Danny Care (Harlequins, 71 caps) (vice-captain)
1 Ellis Genge (Leicester Tigers, 1 cap)
2 Dylan Hartley (Northampton Saints, 84 caps) (captain)
3 Harry Williams (Exeter Chiefs, uncapped)
4 Joe Launchbury (Wasps, 42 caps)
5 Charlie Ewels (Bath Rugby, 3 caps)
6 Mark Wilson (Newcastle Falcons, uncapped)
7 Tom Curry (Sale Sharks, uncapped)
8 Nathan Hughes (Wasps, 8 caps)
Replacements
16 Jack Singleton (Worcester Warriors, uncapped)
17 Matt Mullan (Wasps, 15 caps)
18 Will Collier (Harlequins, uncapped)
19 Nick Isiekwe (Saracens, uncapped)
20 Don Armand (Exeter Chiefs, uncapped)
21 Jack Maunder (Exeter Chiefs, uncapped)
22 Piers Francis (Northampton Saints, uncapped)
23 Denny Solomona (Sale Sharks, uncapped)
The Leicester Tigers prop, named Young Player of the Year and Newcomer of the Year by supporters at the end of his first full season at the club, wins his second cap at loosehead prop.
George Ford, who rejoins Leicester this summer, is at fly-half and is one of the vice-captains in a team led by Dylan Hartley.
England head coach Eddie Jones gives international debuts to Tom Curry, Alex Lozowski, Harry Williams and Mark Wilson, with seven more uncapped players on the bench.
Hartley wins his 85th cap and will move ahead of former captain Martin Johnson and alongside Rory Underwood and Lawrence Dallaglio as the third-most-capped England player of all time.
“I have selected a group of experienced players across the spine of this team as well as four young players who will be eager to go out and play well on their debuts for England,” said Jones.
“I have been impressed with the way the whole squad has trained and gelled together in a short amount of time. They all realise the opportunity that they have to be involved in this England side and I’m sure they will show that commitment on Saturday.
Saturday’s match is shown live on BBC2, kick-off is at 8.15pm UK time.
England (v Argentina)
15 Mike Brown (Harlequins, 60 caps)(vice-captain)
14 Marland Yarde (Harlequins, 11 caps)
13 Henry Slade (Exeter Chiefs, 5 caps)
12 Alex Lozowski (Saracens, uncapped)
11 Jonny May (Gloucester Rugby, 25 caps)
10 George Ford (Bath Rugby, 35 caps)(vice-captain)
9 Danny Care (Harlequins, 71 caps) (vice-captain)
1 Ellis Genge (Leicester Tigers, 1 cap)
2 Dylan Hartley (Northampton Saints, 84 caps) (captain)
3 Harry Williams (Exeter Chiefs, uncapped)
4 Joe Launchbury (Wasps, 42 caps)
5 Charlie Ewels (Bath Rugby, 3 caps)
6 Mark Wilson (Newcastle Falcons, uncapped)
7 Tom Curry (Sale Sharks, uncapped)
8 Nathan Hughes (Wasps, 8 caps)
Replacements
16 Jack Singleton (Worcester Warriors, uncapped)
17 Matt Mullan (Wasps, 15 caps)
18 Will Collier (Harlequins, uncapped)
19 Nick Isiekwe (Saracens, uncapped)
20 Don Armand (Exeter Chiefs, uncapped)
21 Jack Maunder (Exeter Chiefs, uncapped)
22 Piers Francis (Northampton Saints, uncapped)
23 Denny Solomona (Sale Sharks, uncapped)
