The Leicester Tigers full-back, who has 52 senior caps, is among the 10 backs named in the squad by national coach Eddie OSullivan.
There are several new faces named for the first time in an RBS Six Nations match squad, including Leinster hooker Bernard Jackman, No8 Jamie Heaslip and wing Robert Kearney who all played against Murphy for Leinster last weekend.
OSullivan said: The selection was made on the basis of form and, while the response of all of the squad over the last week has been excellent, there were some tight calls to be made. This will be even harder to do next week when we decide the final selection for the game.
Ireland squad (v Italy, TBS 6 Nations Championship, Croke Park, February 2):
Forwards
Rory Best (Belfast Harlequins/Ulster)
Tony Buckley (Shannon/Munster)
Simon Easterby (Llanelli)
John Hayes (Bruff/Munster)
Jamie Heaslip (Clontarf/Leinster)
Marcus Horan (Shannon/Munster)
Bernard Jackman (Clontarf/Leinster)
Denis Leamy (Cork Constitution/Munster)
Donncha OCallaghan (Cork Constitution/Munster)
Mick ODriscoll (Cork Constitution/Munster)
Malcolm OKelly (St.Marys College/Leinster)
David Wallace (Garryowen/Munster)
Backs
Girvan Dempsey (Terenure College/Leinster)
Gordon DArcy (Lansdowne/Leinster)
Robert Kearney (UCD/Leinster)
Geordan Murphy (Leicester Tigers)
Brian ODriscoll (UCD/Leinster)
Ronan OGara (Cork Constitution/Munster)
Eoin Reddan (London Wasps)
Peter Stringer (Shannon/Munster)
Andrew Trimble (Ballymena/Ulster)
Paddy Wallace (Ballymena/Ulster)