Tigers club captain Murphy wins his 70th cap after being named at full-back for Ireland, while England include his club colleagues Dan Cole, Louis Deacon, Tom Croft and Manu Tuilagi in the starting line-up and Toby Flood among the replacements.
Mike Tindall leads the England side and will win his 72nd cap, drawing level with Will Carling as England's most-capped centre.
Ireland (v England, Guinness Summer Series, Aviva Stadium, Saturday 2.30pm)
15 Geordan Murphy (Leicester Tigers)
14 Tommy Bowe (Ospreys)
13 Keith Earls (Young Munster/Munster)
12 Gordon D’Arcy (Lansdowne/Leinster)
11 Andrew Trimble (Ballymena/Ulster)
10 Ronan O'Gara (Cork Constitution/Munster)
9 Eoin Reddan (Lansdowne/Leinster)
1 Cian Healy (Clontarf/Leinster)
2 Jerry Flannery (Shannon/Munster)
3 Mike Ross (Clontarf/Leinster)
4 Donncha O'Callaghan (Cork Constitution/Munster)
5 Paul O’Connell (Young Munster/Munster) Captain
6 Stephen Ferris (Dungannon/Ulster)
7 David Wallace (Garryowen/Munster)
8 Jamie Heaslip (Naas/Leinster)
Replacements
16 Rory Best (Banbridge/Ulster)
17 Tom Court (Malone/Ulster)
18 Donnacha Ryan (Shannon/Munster)
19 Denis Leamy (Cork Constitution/Munster)
20 Conor Murray (Garryowen/Munster)
21 Jonathan Sexton (St. Mary’s College/Leinster)
22 Fergus McFadden (Old Belvedere/Leinster)
England
15 Ben Foden (Northampton Saints)
14 Chris Ashton (Northampton Saints)
13 Manu Tuilagi (Leicester Tigers)
12 Mike Tindall (Gloucester Rugby, captain)
11 Mark Cueto (Sale Sharks)
10 Jonny Wilkinson (Toulon)
9 Richard Wigglesworth (Saracens)
1 Andrew Sheridan (Sale Sharks)
2 Steve Thompson (London Wasps)
3 Dan Cole (Leicester Tigers)
4 Louis Deacon (Leicester Tigers)
5 Courtney Lawes (Northampton Saints)
6 Tom Croft (Leicester Tigers)
7 James Haskell (Ricoh Black Rams)
8 Nick Easter (Harlequins)
Replacements
16 Dylan Hartley (Northampton Saints)
17 Matt Stevens (Saracens)
18 Simon Shaw (Unattached)
19 Tom Wood (Northampton Saints)
20 Joe Simpson (London Wasps)
21 Toby Flood (Leicester Tigers)
22 Delon Armitage (London Irish)
