Murphy, who will make his 49th international appearance, will be up against Tigers team-mate James Hamilton who packs down at lock for the Scots.
The match is the first of two World Cup warm-up fixtures for Eddie O'Sullivan's men, the second being the home tie against Italy at Ravenhill on Friday, August 24.
Ireland vs Scotland at Murrayfield, Saturday, August 11, kick-off 2.30pm
15 Geordan Murphy
14 Brian Carney
13 Brian O'Driscoll (c)
12 Gavin Duffy
11 Tommy Bowe
10 Paddy Wallace
9 Isaac Boss
1 Bryan Young
2 Jerry Flannery
3 Simon Best
4 Malcolm O'Kelly
5 Paul O'Connell
6 Neil Best
7 Stephen Ferris
8 Jamie Heaslip
Replacements
16 Rory Best
17 John Hayes
18 Alan Quinlan
19 Keith Gleeson
20 Eoin Reddan
21 Ronan O'Gara
22 Shane Horgan
