Italian side Viadana will visit Welford Road for a 2pm kick-off on Saturday, January 16.
Tigers claimed a bonus point win from their trip to Viadana in October with a 46-11 success and will be looking for a repeat in a game they must win to keep their hopes of qualifying from Pool 3 alive.
Tigers will then travel to the Liberty Stadium to play Magners League side Ospreys for their final Pool 3 game on Saturday, January 23, kick-off 1.35pm. The two sides met at Welford Road in the opening game of the competition which ended in a thrilling 32-32 draw.
Tickets for the Viadana game are on sale now and available from the Welford Road ticket office on 0844 856 1880 and online.