Youngs, who has made 11 appearances for Leicester Tigers this season, will start at scrum-half while Hurrell has been named on the wing.
Their Tigers teammate Greig Tonks is named among the replacements for the game at Worcester Warriors’ Sixways Stadium on Friday.
England are defending their Six Nations title at this level after completing a clean sweep of victories in 2008 before reaching the final of the Junior World Championship.
Coach Mark Mapletoft said: “We've got a good balance between experience and new players with lots of pressure from the replacements and other guys in the squad for places in the side.
“We've had a lot of tough selection calls to make, which is the way it should be.
“We've got a fair amount of experience for young players, particularly at nine and 10 and I'm sure the expectation will be high because of it.
“That Premiership and first team experience - the likes of Charlie Sharples have been doing well at Moseley for example - should give us players who can help give us shape and direction.
“We're interested in putting together a good performance, we've identified two or three key areas to look at in attack and defence and ultimately we'll judge ourselves on how successful we are at that.”
Please note that this game will be played behind closed doors in the interests of public safety. The decision was made following discussions between Worcester Warriors club, the RFU, both teams involved, emergency services and the Met Office.
Charlie Little, General Manager at Worcester Warriors, said: "This decision was not taken lightly, however public safety concerns were the most important factor in coming to this conclusion.
"With further sub-zero temperatures forecast from early this evening the conditions are set to become extremely hazardous after the game."
England Under 20
15 Charlie Sharples (Gloucester Rugby)
14 Seb Stegmann (Harlequins)
13 Henry Trinder (Gloucester Rugby)
12 Luke Eves (Bristol Rugby)
11 Will Hurrell (Leicester Tigers)
10 Rory Clegg (Newcastle Falcons)
9 Ben Youngs (Leicester Tigers)
1 Ben Moon (Exeter Chiefs)
2 Jamie George (Saracens)
3 Bob Baker (London Wasps)
4 James Gaskell (Sale Sharks)
5 Graham Kitchener (Worcester Warriors)
6 Courtney Lawes (Northampton Saints)
7 Calum Clark (Leeds Carnegie, captain)
8 Chris York (Harlequins)
16 James Clark (London Irish)
17 Shaun Knight (Gloucester Rugby)
18 Dan Williams (Gloucester Rugby)
19 Josh Ovens (Bath Rugby)
20 Dan White (Leeds Carnegie)
21 Rob Miller (Newcastle Falcons)
22 Greig Tonks (Leicester Tigers)