Full-back Murphy won his 63rd cap as a 67th-minute replacement for Ireland and had the honour of bringing the Championship to a close as he kicked the ball dead to confirm a 17-15 win over Wales in Cardiff.
Four Tigers were involved in England’s 26-12 win over Scotland which secured second place in the Championship table for Martin Johnson’s men.
Harry Ellis started each game of the Championship but his 27th cap was ended by injury after just 17 minutes.
By that stage, prop Julian White had joined the action from the replacements’ bench, following a 13th-minute injury to Phil Vickery. White was winning his 49th England cap.
Toby Flood kicked two penalties and a conversion before being replaced by Andy Goode in the 73rd minute, and Tom Croft made his second start of the Championship on the blindside flank before giving way to James Haskell with seven minutes remaining.
England team manager Martin Johnson said: "We were pretty slow out of the blocks but we got our composure back and created some pressure and managed to score some tries."
Tigers prop Martin Castrogiovanni claimed his 59th appearance for Italy as a 58th-minute replacement but was on the wrong end of a 50-8 scoreline against France in Rome.
Greig Tonks had an impressive game at full-back in front of the Sky TV cameras as England Under-20s ended their Six Nations campaign with a 20-6 victory over Scotland at Worcester. Tigers Academy colleague Will Hurrell was used as a 77th-minute replacement on the England wing.