George Chuter, Julian White and Tom Croft are included among the replacements after being released back to the club by the England management.
Murphy’s return means a switch to the wing for Scott Hamilton, who scored the opening try against London Wasps last Sunday.
Matt Smith moves from the wing to join captain Aaron Mauger at centre in the absence of Seru Rabeni who picked up a knee injury at Wasps.
Marcos Ayerza joins Kayser and Castrogiovanni in the front row, with the rest of the pack retaining their places from last week.
“The boys stuck at it really well at Wasps and dug in to take two bonus points,” said acting head coach Richard Cockerill.
“We played some good stuff but we made some basic errors and coughed up some soft points, which we’ve looked at and addressed this week.
“It will be great to get back on home ground after a month away from Welford Road. We need to build on last Sunday’s performance, play our game, look after the ball and make the right decisions at the right time.
“We need to build momentum now to the end of the season.”
Rabeni (knee) and Boris Stankovich (groin) were injured in the match at Wasps, while Dan Hipkiss (knee), Lewis Moody (ankle), Marco Wentzel (back) and Richard Blaze (foot) are still sidelined by injury. Derick Hougaard has returned to training.
Tickets are still available for Saturday’s game at Welford Road. Contact the Tigers ticket office on 08701 28 34 30, book online or visit the stadium.
Leicester Tigers (v Worcester Warriors, Welford Road, 3pm Saturday)
15 Geordan Murphy
14 Scott Hamilton
13 Matt Smith
12 Aaron Mauger (captain)
11 Alesana Tuilagi
10 Sam Vesty
9 Julien Dupuy
1 Marcos Ayerza
2 Benjamin Kayser
3 Martin Castrogiovanni
4 Louis Deacon
5 Ben Kay
6 Craig Newby
7 Ben Woods
8 Jordan Crane