Toby Flood was the only Tigers player in England’s starting XV and was among four England players to receive a yellow card from referee Alain Rolland.
The fly-half, who had kicked England’s opening points of the afternoon, was sin-binned for a high tackle, while Lee Mears, James Haskell and Tom Rees also spent time on the touchline.
"When you play 80 minutes of rugby and 40 of them with 14 men you don't have much of a chance,” said Flood.
“Things didn't go to plan and it wasn't the result we wanted but we fronted up as a team. All in all, we are disappointed with this series."
Flood, who gained 22nd senior cap with his first start of the autumn Test series, added: “This team has huge potential but that's just a word - we need to do lots of hard work when we get back to our clubs and then when we meet up ahead of the Six Nations."
Tigers team-mate Harry Ellis also gained his 22nd cap after replacing Danny Care at scrum-half with 20 minutes remaining.
Tom Croft won his eighth cap as a 67th-minute replacement while Dan Hipkiss made his first appearance of the autumn, winning his seventh cap as a 73rd-minute replacement.