"I am obviously very happy with the call-up," said Crane, who made his 10th appearance in Tigers colours during the 28-15 victory over Saracens at Welford Road on New Year's Day. "Hopefully I will get some game-time, but it is just great to be called up into the squad. I am looking forward to joining them for training and then any game-time is a bonus.
"I knew I would have to be patient this season because I am behind Martin Corry but I have been involved in my fair share of games already and I am really enjoying it at Leicester."
Crane has previously captained England at U-18 and U-19 level. He also played in the Grand Slam-winning U-21s last season and had another taste of representative captaincy during the IRB U-21 World Cup last summer after injury to his clubmate Matt Cornwell.
England Saxons, who also include Tigers lock Ben Kay and winger Tom Varndell in a 32-man squad, face Italy A on February 2 at Exeter Chiefs then go to Belfast to face Ireland A on February 9.