England ran in seven tries in all, with Leicester Tigers centre Tuilagi scoring the last two tries to take the Red Rose past the 50-point mark.
Gloucester wing Charlie Sharples scored his first two Test tries, including the first of the game after 22 minutes. And there were also scores for Ugo Monye (Harlequins), Tom Johnson (Exeter Chiefs) and a penalty try.
His Tigers team-mate Toby Flood landed four conversions and three penalties to take him past 250 points for England.
Tigers were represented by seven players in the England side, including Tom Youngs who made his Test debut, and Fiji centre Vereniki Goneva. Youngs was joined on the pitch in the second-half by brother Ben, who was on the replacements’ bench, while Dan Cole, Flood, Geoff Parling, Tuilagi and Thomas Waldrom all started the game for England.
Elsewhere, Marcos Ayerza played his part as Argentina beat Wales 26-12 at the Millennium Stadium in Cardiff. Second-half tries from wings Juan Imhoff and Gonzalo Camacho helped inflict defeat on Wales, the current RBS 6 Bations champions.
In Brescia, Martin Castrogiovanni's Italy hosted Steve Mafi's Tonga.
Castrogiovanni came off the bench to help Italy win a second-half penalty try as The Azzurri beat Tonga 28-23 in Brescia. Front-rowers Lorenzo Cittadini and Leonardo Ghiraldini scored first-half tries for Italy, while Sona Taumalolo and Fetu'u Vainikolo scored the Tonga tries.