Tigers host Edinburgh on Saturday and head coach Loffreda, settling in after his first full week at Welford Road, said: "We lost the first game in this competition last season and had to react in a positive way. Now we have to do the same this year. We have to get on with the hard work."
Loffreda joined the team in time for the Heineken Cup opener in Dublin last week, when Tigers lost 22-9 to Leinster, and has also seen the Development XV in action twice, at Worcester in his first day at the club and in victory over Newcastle on Monday night.
He has been working with the players this week back at Oval Park in preparation for the home date with Edinburgh.
"I have been working with Richard Cockerill and he is an outstanding person and coach," Loffreda said. "He did many good things during the period before I arrived, he knows the players and I am relying on him. I am sure we will work well in partnership."
With his World Cup triumphs with Argentina and the move to a new country, it is a breathless period for the former international centre.
"It is hard work, I have not had much time to rest, but I am looking forward to the challenge here," Loffreda said. "I know it was a big challenge."
Loffreda is anticipating a tough test against an Edinburgh side now coached by former England chief Andy Robinson.
"Edinburgh are a good team, we have seen them. They play a strong and fast game," he said. "I am sure Andy Robinson will bring some of his character to his Edinburgh team, I saw that in their last performances against Munster and Toulouse."
Tickets for Marcelo Loffreda's first game in charge of Leicester Tigers, against Edinburgh on Saturday, are available now. Contact the Tigers ticket office on 08701 28 34 30, book online or call in at Welford Road.