As the top two sides in the table, Gloucester and Tigers go into the game in impressive form, boasting one defeat each in their last five Premiership games.
Both sides will be without several senior internationals, with the Tigers quartet of Ben Kay, James Hamilton, Geordan Murphy and Martin Castrogiovanni involved in the RBS 6 Nations Championship - but Jordan Crane, Tom Varndell and Ollie Smith will be available for selection after England Saxons announced a revised squad for their fixture against Italy A.
“Gloucester are one of the best teams in the Premiership, they do many things well,” said Tigers head coach Loffreda.
“They work hard, they try to be efficient in the set-piece and also in their continuity. They also have an excellent mind-set that maybe gives them the difference over other teams.
“I think we must focus not on the league table but on our own game and the intensity of the game we have to play.
“We have to be consistent and reach the levels we have done in the last couple of games. We want that to continue, we want to improve every weekend. I think we are doing that. We want to try to keep the momentum now.”
Loffreda will not finalise his selection plans until later this week after monitoring the injury reports, though only Harry Ellis and Alesana Tuilagi are considered long-term injury doubts.
Lewis Moody has returned to the club for treatment on an injury after being ruled out of England’s Six Nations match against Italy in Rome.
“Lewis has a problem with his Achilles,” Loffreda said. “He is not going to be fit for this week but maybe in two weeks he will be fit. It is the same problem he had two or three weeks ago when he could not play for us. It is not a long-term thing to fix.”