The Leicester Tigers flanker is included on the bench as England head to Scotland in the fourth round of the RBS 6 Nations.
“It is going to be very difficult,” Moody said. “Scotland provides its own unique challenge, they get very excited about playing England.
“They have been playing some good rugby this season and they should have beaten Wales, which would have given them a huge confidence going forward. We know the passion up there and it is always a very tough encounter.”
While Moody hopes to earn his 60th senior cap at Murrayfield, Tigers colleague Ben Youngs starts alongside him on the bench as the only uncapped member of the matchday 22.
“It is great to see Ben in the squad,” said Moody. “He has been playing awesomely all year and it is a great chance for him if he gets on.”
Kick-off at Murrayfield is at 5pm, with full live coverage on BBC TV.