Tigers recorded a 28-17 victory over Wales Under-18s a fortnight ago on home turf after a narrow 19-12 defeat by England Under-18s a week earlier.
Now the team have a third opportunity to test themselves against representative opposition and play at the club's famous stadium.
"We're delighted to host another representative team and for our players to have another opportunity to play at Welford Road," said Tigers Academy manager Neil McCarthy.
"These fixtures are important is providing another development opportunity for our young players and a chance for supporters to come down and see them at the club's home stadium."
The match against Canada Under-20s is 1pm kick-off and admission is free to all supporters at the Holland & Barrett Stand turnstiles. The ABC Bar will be open. Parking is available on a first-come first-served basis in the Crumbie car park.