Springbok newcomer Davon Raubenheimer has been promoted to the starting XV for the opening game of South Africa's European tour against Leicester Tigers at Welford Road on Friday.
Raubenheimer takes the place of Heinrich Brüssow and will wear the number seven jersey with Dewald Potgieter switching to six.
Jean Deysel has been called up to replace Spies and has been included on the bench for Friday's sell-out clash against Tigers.
"Losing Pierre is a blow for us and a disappointment for him, but we are fortunate to have strong back-up players in the squad who are familiar with how we want to play," said Bok coach Peter de Villiers.
"I am also confident that the change will not disrupt our preparations for the important tour opener on Friday."
The Springbok squad arrived in England on Wednesday and attended a welcome dinner at Welford Road in the company of Tigers players and supporters.
South Africa team (v Leicester Tigers, Welford Road, Friday 7.30pm):
1 Gurthro Steenkamp
2 Chiliboy Ralepelle (captain)
3 Jannie du Plessis
4 Danie Rossouw
5 Andries Bekker
6 Dewald Potgieter
7 Davon Raubenheimer
8 Ashley Johnson
9 Heini Adams
10 Ruan Pienaar
11 Jongi Nokwe
12 Wynand Olivier
13 Juan de Jongh
14 Odwa Ndungane
15 Earl Rose
Replacements
16 Bandise Maku
17 Heinke van der Merwe
18 Alistair Hargreaves
19 Jean Deysel
20 Francois Hougaard
21 Meyer Bosman
22 Riaan Viljoen
Raubenheimer takes the place of Heinrich Brüssow and will wear the number seven jersey with Dewald Potgieter switching to six.
Jean Deysel has been called up to replace Spies and has been included on the bench for Friday's sell-out clash against Tigers.
"Losing Pierre is a blow for us and a disappointment for him, but we are fortunate to have strong back-up players in the squad who are familiar with how we want to play," said Bok coach Peter de Villiers.
"I am also confident that the change will not disrupt our preparations for the important tour opener on Friday."
The Springbok squad arrived in England on Wednesday and attended a welcome dinner at Welford Road in the company of Tigers players and supporters.
South Africa team (v Leicester Tigers, Welford Road, Friday 7.30pm):
1 Gurthro Steenkamp
2 Chiliboy Ralepelle (captain)
3 Jannie du Plessis
4 Danie Rossouw
5 Andries Bekker
6 Dewald Potgieter
7 Davon Raubenheimer
8 Ashley Johnson
9 Heini Adams
10 Ruan Pienaar
11 Jongi Nokwe
12 Wynand Olivier
13 Juan de Jongh
14 Odwa Ndungane
15 Earl Rose
Replacements
16 Bandise Maku
17 Heinke van der Merwe
18 Alistair Hargreaves
19 Jean Deysel
20 Francois Hougaard
21 Meyer Bosman
22 Riaan Viljoen
