Seymour and Powell were used as replacements in the win over Bath last weekend, while Vyvyan returns to the second row and full-back Wyles is available after Sevens duty with the US Eagles.
Matias Aguero (neck) and Kameli Ratuvou (knee) have been added to the injury list and Alex Goode suffered a head injury against Bath. Chris Jack is unavailable having returned to New Zealand for a week.
"There's been a spring in the step after the Bath game but it's important that we channel that in the right way going into Saturday," said coach Richard Graham.
"We want to go to Welford Road and perform well - if we do that we will give ourselves a really good chance.
"The boys supported each other really well against Bath last week and at no point in the game did we stop believing and that is the same attitude we will need against Leicester. They have been on a good run and winning games at home and away and the game is a really good challenge for us."
Tickets for Saturday are available now from the Tigers ticket office. Phone 08701 28 34 30.
Saracens (v Leicester Tigers, Welford Road, Saturday 2.45pm)
15 Chris Wyles
14 Richard Haughton
13 Adam Powell
12 Brad Barritt
11 Rodd Penney
10 Glen Jackson
9 Justin Marshall
1 Tom Mercey
2 Alex Walker
3 Cobus Visagie
4 Tom Ryder
5 Hugh Vyvyan
6 Wikus van Heerden (c)
7 David Seymour
8 Ben Skirving
Replacements
16 Andy Kyriacou
17 Jordan Mitchell
18 Kris Chesney
19 Don Barrell
20 Mickey Wilson
21 Gordon Ross
22 Edd Thrower
