Seven Leicester Tigers players have been selected to play in the England A versus Scotland A fixture on their own home ground at Mattioli Woods Welford Road on Sunday.
Five Leicester players had already been named in the England team for this opening game of each country’s summer international series.
With 39 senior caps, Scott is the most experienced member of the Scottish squad and has been named to lead out the team by interim head coach Mike Blair while Henderson is among 17 uncapped players in the matchday squad.
Nine players are isolating following a positive Covid-19 case earlier this week, with Stafford McDowall, Callum Hunter-Hill, Ben Vellacott and George Taylor called up and going straight in to the matchday 23.
Blair said: “We’ve clearly had a bit of disruption this week, but the medical team and our playing squad have handled the situation extremely professionally.
“It is unfortunately a reminder of the world we’re currently living in and the players are now isolating as per Scottish Government guidelines.
“Despite this, we’ve still had a really good training week, with this young and talented squad maintaining the high standards and levels of enthusiasm that we expect while in Scotland camp.
“As we’ve said all week, we’re treating this ‘A’ game like a Test match, and so the build-up and processes that we go through on a weekly basis have remained the same.”
Ellis Genge is vice-captain of England A, providing international experience of 28 Test caps alongside uncapped colleagues Harry Wells, Joe Heyes, Dan Kelly and Freddie Steward also in the starting XV.
A small number of tickets remain on sale at the Tigers ticket office. Book online or phone 0116 319 8888 (option 2).
15 Freddie Steward (Leicester Tigers, uncapped)
14 Adam Radwan (Newcastle Falcons, uncapped)
13 Ollie Lawrence (Worcester Warriors, 6 caps)
12 Dan Kelly (Leicester Tigers, uncapped)
11 Max Malins (Bristol Bears, on loan from Saracens, 7 caps)
10 Jacob Umaga (Wasps, uncapped)
9 Harry Randall (Bristol Bears, uncapped)
1 Ellis Genge (Leicester Tigers, 28 caps)
2 Curtis Langdon (Sale Sharks, uncapped)
3 Joe Heyes (Leicester Tigers, uncapped)
4 Harry Wells (Leicester Tigers, uncapped)
5 Charlie Ewels (Bath Rugby, 21 caps)
6 Lewis Ludlow (c) (Gloucester Rugby, uncapped)
7 Ben Curry (Sale Sharks, uncapped)
8 Callum Chick (Newcastle Falcons, uncapped)
16 Jamie Blamire (Newcastle Falcons, uncapped)
17 Beno Obano (Bath Rugby, 1 cap)
18 Trevor Davison (Newcastle Falcons, uncapped)
19 Ted Hill (Worcester Warriors, 1 cap)
20 Lewis Ludlam (Northampton Saints, 8 caps)
21 Dan Robson (Wasps, 12 caps)
22 George Furbank (Northampton Saints, 3 caps)
23 Joe Cokanasiga (Bath Rugby, 9 caps)
15 Damien Hoyland (Edinburgh Rugby)
14 Rufus McLean (Glasgow Warriors)
13 Matt Scott (Leicester Tigers) (c)
12 Stafford McDowall (Glasgow Warriors)
11 Blair Kinghorn (Edinburgh Rugby)
10 Ross Thompson (Glasgow Warriors)
9 Charlie Shiel (Edinburgh Rugby)
1 Nick Auterac (Northampton Saints)
2 Ewan Ashman (Sale Sharks)
3 Oli Kebble (Glasgow Warrriors)
4 Cameron Henderson (Leicester Tigers)
5 Kiran McDonald (Glasgow Warriors)
6 Josh Bayliss (Bath Rugby)
7 Rory Darge (Glasgow Warriors)
8 Magnus Bradbury (Edinburgh Rugby)
16 Adam McBurney (Ulster Rugby)
17 Robin Hislop (Doncaster Knights)
18 Javan Sebastian (Scarlets)
19 Jamie Hodgson (Edinburgh Rugby)
20 Callum Hunter-Hill (Saracens)
21 Ben Vellacott (Wasps)
22 Adam Hastings (Glasgow Warriors)
23 George Taylor (Edinburgh Rugby)