Six clubs can qualify for the Guinness Premiership semi-finals and a further four will be trying to claim a place in the Heineken Cup for next season.
Premier Rugby chief executive Mark McCafferty said, "This season the league has been closer than ever before and that is saying something considering the finishes we have had in the past.
"The final weekend is always a fascinating one for neutrals and a nerve-wracking one for supporters. I am sure the final 80 minutes of the season on Saturday will provide a fitting conclusion to a fantastically competitive season of Guinness Premiership rugby."
Leicester Tigers have already qualified for a fifth successive semi-final spot and are guaranteed to be at home. A point against Bristol Rugby will make them No.1 seeds.
A bonus-point win against Newcastle Falcons will guarantee Harlequins a home semi-final. Two match points will ensure a place in the semi-final for the first time. Quins have not finished in the top four since 1998/99.
Bath Rugby need two points at home to Saracens to guarantee a place in the top four for the second year running. Bath reached the Premiership Final in 2003/04 but lost to London Wasps.
London Irish also need two points at Sixways to guarantee a place in the top four for the first time since 2005/06.
Gloucester Rugby have to win at Adams Park against reigning champions London Wasps, ideally with a try bonus point, to give themselves any chance of making the last four for a third year in a row. That will not be enough if Harlequins, Bath and Irish all get a minimum of two points.
Sale Sharks must win with a bonus point against Northampton Saints to give themselves any chance of making the top four for the first time since they were champions in 2005/06. Even that won't be enough if Harlequins, Bath and Irish all get a point, or Gloucester also win.
The battle is just as fierce for the remaining Heineken Cup places. All of the top six clubs have already secured Heineken Cup spots for next season, but Northampton, Wasps, Saracens and Newcastle could put themselves in the frame for a seventh-place finish and a potential Heineken Cup spot. Seventh place would qualify a club for Europe if Bourgoin go on to win the European Challenge Cup.
Northampton, Saracens and Worcester Warriors could qualify for the Heineken Cup by winning the European Challenge Cup, with the semi-final of that competition taking place next weekend. Saracens travel to Franklin's Gardens to play Northampton and Worcester travel to Bourgoin.
All six Guinness Premiership matches kick-off at 3pm on Saturday, with Sky Sports televising the clash at the Recreation Ground between Bath and Saracens. Sky will have cameras and a live feed at each of the other five matches and will provide regular updates on semi-final and European qualification.
The Guinness Premiership website, www.guinnesspremiership.com will have official live match scoring and updates available under the 'Match Day Live' area of the 'Match Centre'.
The order of the semi-finals will be announced shortly after the final whistle, with the first match at 3pm and the second at 5.30pm on Saturday, May 9.
Remember tickets for the Tigers semi-final go on sale to season ticket holders this weekend. The ticket office at Welford Road will be open from 5pm on Saturday, after the Bristol match, and 10am-4pm on Sunday. Tickets will be made available to members from next Thursday and on general sale from next Friday. Ticket prices are £15 adults, £10 concessions, £5 juniors and £35 for a family ticket.
