Ben Youngs and Manu Tuilagi return to the England starting line-up for the game against Ireland at Twickenham this weekend.
Scrum-half Youngs win his 98th cap after starting on the bench against Scotland last time out, while Tuilagi is back in the England midfield after recovering from a groin injury.
Their Leicester Tigers colleagues Jonny May and George Ford both start in the backline, with Ellis Genge among the replacements after his tryscoring performance against the Scots.
Elliot Daly is moved to full-back with Jonathan Joseph, who will win his 50th cap, on the wing.
England head coach Eddie Jones said: “Ireland are a very good team, extremely well-coached. They are a team we respect a lot. They are a tactically smart team. Murray and Sexton, who have played 170 Tests between them, will manage the game well. We’ve got to make sure we match their physicality and their emotion.”
England versus Ireland in the third round of the Guinness Six Nations is a 3.00pm kick-off on Sunday and will be shown live on ITV1.
England (v Ireland, Twickenham, Sunday 3,00pm)
15 Elliot Daly (Saracens, 41 caps)
14 Jonny May (Leicester Tigers, 54 caps)
13 Manu Tuilagi (Leicester Tigers, 41 caps)
12 Owen Farrell (Saracens, 81 caps) (c)
11 Jonathan Joseph (Bath Rugby, 49 caps)
10 George Ford (Leicester Tigers, 67 caps)
9 Ben Youngs (Leicester Tigers, 97 caps)
1 Joe Marler (Harlequins, 69 caps)
2 Jamie George (Saracens, 47 caps)
3 Kyle Sinckler (Harlequins, 33 caps)
4 Maro Itoje (Saracens, 36 caps)
5 George Kruis (Saracens, 43 caps)
6 Courtney Lawes (Northampton Saints, 83 caps)
7 Sam Underhill (Bath Rugby, 17 caps)
8 Tom Curry (Sale Sharks, 21 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 22 caps)
17 Ellis Genge (Leicester Tigers, 16 caps)
18 Will Stuart (Bath Rugby, 1 cap)
19 Joe Launchbury (Wasps, 63 caps)
20 Charlie Ewels (Bath Rugby, 13 caps)
21 Ben Earl (Saracens, 1 cap)
22 Willi Heinz (Gloucester Rugby, 11 caps)
23 Henry Slade (Exeter Chiefs, 27 caps)
Ireland: 15 Jordan Larmour (St Mary’s College/Leinster) 23 caps, 14 Andrew Conway (Garryowen/Munster) 20 caps, 13 Robbie Henshaw (Buccaneers/Leinster) 42 caps, 12 Bundee Aki (Galwegians/Connacht) 25 caps, 11 Jacob Stockdale (Lurgan/Ulster) 27 caps, 10 Jonathan Sexton (St Marys College/Leinster) (c) 90 caps, 9 Conor Murray (Garryowen/Munster) 80 caps; 1 Cian Healy (Clontarf/Leinster) 97 caps, 2 Rob Herring (Ballynahinch/Ulster) 10 caps, 3 Tadhg Furlong (Clontarf/Leinster) 43 caps, 4 Iain Henderson (Academy/Ulster) 55 caps, 5 James Ryan (UCD/Leinster) 25 caps, 6 Peter O’Mahony (Cork Constitution/Munster) 66 caps, 7 Josh van der Flier (UCD/Leinster) 25 caps, 8 CJ Stander (Shannon/Munster) 40 caps
Replacements: 16 Ronan Kelleher (Lansdowne/Leinster) 2 caps, 17 Dave Kilcoyne (UL Bohemians/Munster) 38 caps, 18 Andrew Porter (UCD/Leinster) 25 caps, 19 Devin Toner (Lansdowne/Leinster) 69 caps, 20 Caelan Doris (St Mary’s College/Leinster) 1 cap, 21 John Cooney (Terenure College/Ulster) 10 caps, 22 Ross Byrne (UCD/Leinster) 5 caps, 23 Keith Earls (Young Munster/Munster) 83 caps