Mulipola has been sidelined since suffering a calf injury playing for Samoa against Ireland in the autumn but returns this week to join Marcos Ayerza and Rob Hawkins in the Tigers front row.
Ben Youngs and Ed Slater return from England’s Six Nations squad and go straight into the Leicester line-up which will be led by skipper Toby Flood.
Mathew Tait is among the senior players returning after sitting out the LV= Cup weeks, while Blaine Scully and Vereniki Goneva are on the wings with Adam Thompstone ruled out after taking a knock in his England Saxons debut against Scotland ‘A’ last Friday.
Internationals Steve Mafi, Pablo Matera and Scott Hamilton are included among the replacements and there is a place for England Under-20s hooker Harry Thacker in an Aviva Premiership matchday squad for the first time.
Leicester Tigers (v Worcester Warriors, away, Friday 7.45pm)
15 Mathew Tait
14 Blaine Scully
13 Matt Smith
12 Anthony Allen
11 Vereniki Goneva
10 Toby Flood (c)
9 Ben Youngs
1 Marcos Ayerza
2 Rob Hawkins
3 Logovi’i Mulipola
4 Louis Deacon
5 Ed Slater
6 Jamie Gibson
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 Harry Thacker
17 Boris Stankovich
18 Fraser Balmain
19 Steve Mafi
20 Pablo Matera
21 David Mélé
22 Owen Williams
23 Scott Hamilton
Worcester Warriors
15 Chris Pennell
14 Josh Drauniniu
13 Alex Grove
12 Ravai Fatiaki
11 David Lemi
10 Paul Warwick
9 Jonny Arr
1 Ofa Fainga'anuku
2 Agustin Creevy
3 John Andress
4 James Percival
5 Mariano Galarza
6 Mike Williams
7 Sam Betty
8 Jonathan Thomas (c)
Replacements
16 Ed Shervington
17 George Porter
18 Rob O'Donnell
19 Dean Schofield
20 Leonardo Senatore
21 Paul Hodgson
22 Ignacio Mieres
23 Josh Matavesi
