Leicester Tigers centre Charlie Thacker will make his England Under-20s debut against Italy this weekend.Eighteen-year-old Thacker comes into the England line-up as the only change from the side that opened the Six Nations with defeat in Wales last weekend. He replaces Bath’s Max Clark.   Club colleagues Charlie Beckett and Will Owen keep their places in the England back row, with hooker Jake Farnworth also in the 23-man squad.   England are looking to bounce back from their 21-15 defeat against Wales, and forwards coach Ian Peel said: “The lads have responded very well this week. They were gutted after the Wales result but have taken a lot from that game and we’re looking to transfer that from training pitch to the game.”   This match is at Brickfields, Plymouth on Friday. Kick-off is at 7.45pm and the game is to be shown live on Sky Sports. Tigers development squad wing Rhys Williams is among the replacements for Wales Under-20s as they prepare to face Scotland on Friday.   England Under-20s 15 Piers O'Conor (Wasps) 14 George Perkins (Saracens) 13 Joe Marchant (Harlequins) 12 Charlie Thacker (Leicester Tigers) 11 Howard Packman (Northampton Saints) 10 Rory Jennings (Bath Rugby) 9 Stuart Townsend (Exeter Chiefs) 1 Ellis Genge (Bristol Rugby) 2 Jack Walker (Yorkshire Carnegie) 3 Paul Hill (Yorkshire Carnegie) 4 Kieran Treadwell (Harlequins) 5 Charlie Ewels (Bath Rugby)(c) 6 Charlie Beckett (Leicester Tigers) 7 Will Owen (Leicester Tigers) 8 James Chisholm (Harlequins)   Replacements 16 Jake Farnworth (Leicester Tigers) 17 Tom West (Wasps Rugby) 18 Ciaran Parker (Sale Sharks) 19 Joe Batley (Gloucester Rugby) 20 Sam Skinner (Exeter Chiefs) 21 James Mitchell (Sale Sharks) 22 Tom Morton (Sale Sharks) 23 Tom Howe (Wasps Rugby)