Tigers scrum-half Youngs and fly-half Flood make their third start of the autumn internationals in a line-up that shows four changes to the one that beat Australia 35-18.
Dan Cole and Tom Croft are on the bench with David Wilson (Bath Rugby) and James Haskell (Stade Francais) taking over in the front and back rows respectively.
Harlequins No8 leads the side, taking over from Lewis Moody (Bath Rugby) and Matt Banahan (Bath Rugby) replaces Mike Tindall (Gloucester Rugby) at outside centre. David Attwood (Gloucester Rugby) is added to the replacements in place of Simon Shaw (London Wasps).
England (v Samoa, Investec International, Saturday, November 20 2.30pm)
15 Ben Foden (Northampton Saints)
14 Chris Ashton (Northampton Saints)
13 Matt Banahan (Bath Rugby)
12 Shontayne Hape (Bath Rugby)
11 Mark Cueto (Sale Sharks)
10 Toby Flood (Leicester Tigers)
9 Ben Youngs (Leicester Tigers)
1 Andrew Sheridan (Sale Sharks)
2 Dylan Hartley (Northampton Saints)
3 David Wilson (Bath Rugby)
4 Courtney Lawes (Northampton Saints)
5 Tom Palmer (Stade Francais)
6 James Haskell (Stade Francais)
7 Hendre Fourie (Leeds Carnegie)
8 Nick Easter (Harlequins, Captain)
Replacements
16 Steve Thompson (Leeds Carnegie)
17 Dan Cole (Leicester Tigers)
18 David Attwood (Gloucester Rugby)
19 Tom Croft (Leicester Tigers)
20 Danny Care (Harlequins)
21 Charlie Hodgson (Sale Sharks)
22 Delon Armitage (London Irish)
