Christophe Laussucq and Dave Young will make their first Guinness Premiership starts for Tigers, while Jordan Crane comes into the back row for his first start of the season.
France international scrum-half Laussucq has been on the bench for the opening league wins over Bristol and Bath while prop Young was an early replacement for Julian White during the victory over Bath and is promoted to the starting line-up.
Brett Deacon moves across to blindside flanker for his third start of the season, while Crane take the No.8 shirt. Owen Finegan is sidelined by injury.
Outside Laussucq, the backline is the same as started the 26-16 victory over Bath at Welford Road last Saturday.
Ben Youngs makes his first appearance of the season in the matchday squad as he is named on the bench, while Samoa winger Alesana Tuilagi is selected in the 22 as the first player to return to the club from the Rugby World Cup.
In announcing his selection, acting head coach Cockerill said: "Julian White suffered a neck injury last week and Ayoola Erinle's hamstring has not quite recovered, but Dave Young stepped up well and Matt Smith came on to the wing and did a good job. That is what having a good squad is all about.
"Christophe Laussucq has a huge amount of experience with some big clubs and we want to see what he can do for us."
After the weekend's game, Tigers return to home soil to host Gloucester on Saturday, October 6 (6.00pm kick-off). Tickets are available now, contact the Tigers ticket office on 08701 28 34 30.
Leicester Tigers (versus London Wasps, away, Sunday 3.00pm)
15 Johne Murphy
14 Matt Smith
13 Ollie Smith
12 Sam Vesty
11 Tom Varndell
10 Andy Goode
9 Christophe Laussucq
1 Boris Stankovich
2 Benjamin Kayser
3 Dave Young
4 Louis Deacon (captain)
5 Marco Wentzel
6 Brett Deacon
7 Luke Abraham
8 Jordan Crane
Replacements
16 Mefin Davies
17 Alex Moreno
18 Richard Blaze
19 Tom Croft
20 Ben Youngs
21 Matt Cornwell
22 Alesana Tuilagi
