The 24-year-old international back-rower will lead out a team which includes Horacio Agulla and Rob Hawkins for their first start since joining Tigers in the summer.
Hawkins joins Boris Stankovich and Dan Cole in the front row, while Agulla lines up on the wing.
George Chuter and Ben Youngs are rested in line with the England EPS agreement, and director of rugby Richard Cockerill makes a number of changes to the line-up as Geordan Murphy, Alesana Tuilagi, Ben Woods and Thomas Waldrom sit out after starting the opening four games of the season.
“We were much better against Leeds last week in terms of ball control and decision-making,” said Cockerill.
“Saracens have started the season pretty well but we go there in good spirits. We’ve had a few injuries in the opening weeks of the season, but the guys who have been playing have taken their chance and they’ve been playing well.
"We’ve also been able to bring in some fresh legs this weekend and rotate some of the squad which is important too in a long season.”
International props Martin Castrogiovanni and Julian White are among the replacements, together with fly-half George Ford. Lee Robinson is included in the matchday 23 for the first time since his summer switch from Bristol.
Marcos Ayerza and Jeremy Staunton missed last week’s win over Leeds Carnegie with injury and Manu Tuilagi is also ruled out this week. Anthony Allen, Toby Flood, Jordan Crane, Richard Blaze, Geoff Parling and Louis Deacon are also currently sidelined.
Leicester Tigers (v Saracens, Vicarage Road, Sunday 4.30pm)
15 Lucas Amorosino
14 Scott Hamilton
13 Dan Hipkiss
12 Matt Smith
11 Horacio Agulla
10 Billy Twelvetrees
9 James Grindal
1 Boris Stankovich
2 Rob Hawkins
3 Dan Cole
4 Ed Slater
5 George Skivington
6 Tom Croft (c)
7 Craig Newby
8 Ben Pienaar
Replacements
16 Joe Duffey
17 Martin Castrogiovanni
18 Julian White
19 Steve Mafi
20 Ben Woods
21 Sam Harrison
22 George Ford
23 Lee Robinson
Saracens director of rugby Brendan Venter makes five changes to his starting team with Richard Wigglesworth, Schalk Brits, Hugh Vyvyan, Michael Tagicakibau and Petrus du Plessis coming into the starting line-up on rotation.
Nils Mordt switches to inside centre with Brad Barritt on the bench. Also among the replacements, Andy Saull is in line for his first appearance of the season after missing the opening weeks of the campaign with a broken hand.
Saracens: 15 Chris Wyles, 14 David Strettle, 13 Kameli Ratuvou, 12 Nils Mordt, 11 Michael Tagicakibau, 10 Derick Hougaard, 9 Richard Wigglesworth; 1 Deon Carstens, 2 Schalk Brits, 3 Petrus du Plessis, 4 Steve Borthwick (c), 5 Hugh Vyvyan, 6 Kelly Brown, 7 Jacques Burger, 8 Ernst Joubert. Replacements: 16 Jamie George, 17 Matt Parr, 18 Carlos Nieto, 19 Mouritz Botha, 20 Andy Saull, 21 Neil de Kock, 22 Brad Barritt, 23 Adam Powell
