Manu Tuilagi has been called in to the England side among the replacements after head coach Eddie Jones was forced in to a handful of changes to his team to play Wales at Twickenham Stadium due to injuries.
Tuilagi joins Tigers team-mates Dan Cole, Ellis Genge, George Ford and Ben Youngs in the matchday squad for the Quilter International.
Elsewhere, Joe Cokanasiga (Bath Rugby) replaces club mate Ruaridh McConnochie (hip) on the right wing while Jonathan Joseph (Bath Rugby) will play at outside centre instead of Henry Sade (knee).
Tom Curry (Sale Sharks) switches to openside flanker with Lewis Ludlam (Northampton Saints) coming in for Bath Rugby’s Sam Underhill (toe) to play on the blindside.
Courtney Lawes (Northampton Saints) and Tuilagi are included as changes on the bench.
England starting XV
15 Elliot Daly (Saracens, 30 caps)
14 Joe Cokanasiga (Bath Rugby, 4 caps)
13 Jonathan Joseph (Bath Rugby, 40 caps)
12 Piers Francis (Northampton Saints, 4 caps)
11 Anthony Watson (Bath Rugby, 33 caps)
10 George Ford (Leicester Tigers, 55 caps) C
9 Willi Heinz (Gloucester Rugby, uncapped) VC
1 Ellis Genge (Leicester Tigers, 9 caps)
2 Luke Cowan-Dickie (Exeter Chiefs, 11 caps)
3 Dan Cole (Leicester Tigers, 85 caps)
4 Joe Launchbury (Wasps, 58 caps)
5 Charlie Ewels (Bath Rugby, 10 caps)
6 Lewis Ludlam (Northampton Saints, uncapped)
7 Tom Curry (Sale Sharks, 10 caps)
8 Billy Vunipola (Saracens, 41 caps)
16 Jack Singleton (Saracens, uncapped)
17 Joe Marler (Harlequins, 59 caps)
18 Harry Williams (Exeter Chiefs, 17 caps)
19 George Kruis (Saracens, 32 caps)
20 Courtney Lawes (Northampton Saints, 71 caps)
21 Ben Youngs (Leicester Tigers, 85 caps)
22 Joe Marchant (Harlequins, uncapped)
23 Manu Tuilagi (Leicester Tigers, 32 caps)