Ellis Genge, who was originally named to play, has been withdrawn after a positive COVID-19 test.
The Tigers duo have been retained to start by Eddie Jones from the side that defeated Tonga in the opening round of the Autumn series last weekend.
Supporters can watch live coverage of England versus Australia live on a big screen in Final Whistle on Saturday following the Tigers match against Sale Sharks in the Premiership Rugby Cup.
Scott has been named to start at inside-centre, while Wiese has been included among the Springboks replacements.
Meanwhile, Leicester duo Julián Montoya and Matías Moroni start for Argentina in their Test match against Italy.
Montoya, who will captain the Los Pumas, starts at hooker and Moroni at outside-centre.