The England international has not started a game since scoring a hat-trick of tries in the Heineken Cup win over Benetton Treviso at the end of January.
Crane is named in the No8 shirt, with Thomas Waldrom named among the replacements.
The backline involved in the win over Bath Rugby last weekend is retained for the trip to the Twickenham Stoop.
Martin Castrogiovanni and George Skivington return to the matchday squad after missing the trip to Bath.
Leicester Tigers (v Harlequins, away, Saturday 5.30pm)
15 Scott Hamilton
14 Horacio Agulla
13 Manu Tuilagi
12 Anthony Allen
11 Alesana Tuilagi
10 Toby Flood
9 Ben Youngs
1 Marcos Ayerza
2 George Chuter
3 Dan Cole
4 Steve Mafi
5 Ed Slater
6 Tom Croft
7 Craig Newby (c)
8 Jordan Crane
Replacements
16 Rob Hawkins
17 Boris Stankovich
18 Martin Castrogiovanni
19 George Skivington
20 Thomas Waldrom
21 James Grindal
22 Jeremy Staunton
23 Matt Smith
Fly-half Nick Evans returns for Harlequins after injury and lines up next to England international Danny Care.
Harlequins: 15 Mike Brown, 14 Gonzalo Camacho, 13 George Lowe, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care; 1 Joe Marler, 2 Joe Gray, 3 John Andress, 4 Ollie Kohn, 5 George Robson, 6 Maurie Fa'asavalu, 7 Chris Robshaw (c), 8 Nick Easter. Replacements: 16 Matt Cairns, 17 Ceri Jones, 18 Mark Lambert, 19 Tomas Vallejos, 20 Will Skinner, 21 Dave Moore, 22 Rory Clegg, 23 Tom Williams
