England head coach Eddie Jones brings captain Dylan Hartley back into the starting line-up after recovering from injury, while Kyle Sinckler starts at tighthead prop. George Kruis comes in to partner Saracens colleague Maro Itoje in the second row while James Haskell starts at openside flanker with Chris Robshaw moving to the blindside.
Saracens clubmates Richard Wigglesworth and Owen Farrell start as the half-back pairing as Ben Te’o and Jonathan Joseph join forces in midfield.
Don Armand, who was called into the squad this week after injuries to Courtney Lawes and Nathan Hughes, is among the replacements.
Head coach Jones said: “We can’t wait to get back to Twickenham. We have had a couple of tough games on the road and to get back and play in front of our 24th man will be exciting for the players and they will be looking forward to putting in a good performance.
“Ireland is a very good team. We have seen in every game the physical contest has been quite enormous so we have to meet that physical challenge and then play smart tactically.”
England against Ireland is a 2.45pm kick-off on Saturday.
Supporters can watch all the action from the final weekend of the Six Nations at Welford Road on Saturday. Tigers will be hosting an International Sports Bar in the Clubhouse at the Robin Hood Stand end of the ground. For more details, and to book your place, click here.
England (v Ireland)
15 Anthony Watson (Bath Rugby, 32 caps)
14 Jonny May (Leicester Tigers, 33 caps)
13 Jonathan Joseph (Bath Rugby, 39 caps)
12 Ben Te’o (Worcester Warriors, 12 caps)
11 Elliot Daly (Wasps, 17 caps)
10 Owen Farrell (Saracens, 57 caps)
9 Richard Wigglesworth (Saracens, 30 caps)
1 Mako Vunipola (Saracens, 48 caps)
2 Dylan Hartley (Northampton Saints, 92 caps)
3 Kyle Sinckler (Harlequins, 9 caps)
4 Maro Itoje (Saracens, 18 caps)
5 George Kruis (Saracens, 24 caps)
6 Chris Robshaw (Harlequins, 63 caps)
7 James Haskell (Wasps, 76 caps)
8 Sam Simmonds (Exeter Chiefs, 6 caps)
16 Jamie George (Saracens, 24 caps)
17 Joe Marler (Harlequins, 55 caps)
18 Dan Cole (Leicester Tigers, 81 caps)
19 Joe Launchbury (Wasps, 51 caps)
20 Don Armand (Exeter Chiefs, 1 cap)
21 Danny Care (Harlequins, 80 caps)
22 George Ford (Leicester Tigers, 44 caps)
23 Mike Brown (Harlequins, 68 caps)