Dan Cole, George Ford and Jonny May have all been named in the England side to play France in Paris on Saturday (kick-off 4.45pm).
Head coach Eddie Jones has made one change in the pack where Dylan Hartley has been ruled out through injury. Jamie George comes in to start with Luke Cowan-Dickie the replacement hooker.
Owen Farrell will captain the side with his Saracens team-mate Mako Vunipola named as vice-captain.
Ben Te’o will start at outside centre with Elliot Daly returning on the left wing. Anthony Watson moves from right wing to fullback with Jonny May switching wings.
There are six changes among the replacements including Cowan-Dickie, Mike Brown, James Haskell, Jonathan Joseph, Sam Simmonds and Kyle Sinckler.
Jones said: “This game is about the opportunity for the team to move forward and we want a response from the players this week.
“Against France we want to be brutal and aggressive on the gain line and to play with a great tactical discipline.”
15 Anthony Watson (Bath Rugby 31 caps)
14 Jonny May (Leicester Tigers 32 caps)
13 Ben Te’o (Worcester Warriors 11 caps)
12 Owen Farrell (Saracens 56 caps) C
11 Elliot Daly (Wasps 16 caps)
10 George Ford (Leicester Tigers 43 caps)
9 Danny Care (Harlequins 79 caps)
1 Mako Vunipola (Saracens 47 caps) VC
2 Jamie George (Saracens 23 caps)
3 Dan Cole (Leicester Tigers 80 caps)
4 Joe Launchbury (Wasps 50 caps)
5 Maro Itoje (Saracens 17 caps)
6 Courtney Lawes (Northampton Saints 64 caps)
7 Chris Robshaw (Harlequins 62 caps)
8 Nathan Hughes (Wasps 13 caps)
16 Luke Cowan-Dickie (Exeter Chiefs 4 caps)
17 Joe Marler (Harlequins 54 caps)
18 Kyle Sinckler (Harlequins 8 caps)
19 James Haskell (Wasps 75 caps)
20 Sam Simmonds (Exeter Chiefs 5 caps)
21 Richard Wigglesworth (Saracens 29 caps)
22 Jonathan Joseph (Bath Rugby 38 caps)
23 Mike Brown (Harlequins 67 caps)