Tighthead prop David Wilson replaces Dan Cole who will require three months rest from rugby before further assessment on his neck, while the uncapped George Ford comes on to the replacements’ bench for Brad Barritt.
Head coach Stuart Lancaster said: “We are excited about being back at our home after two games on the road. The Twickenham crowd during the November internationals was superb and I’m sure it’ll be the same again on Saturday.
“We have been forced into one change and we wish Dan Cole all the best for his recovery. However, David Wilson is an experienced international with 31 caps and he showed in his three starts against Argentina last year what he can do."
England (v Ireland, RBS 6 Nations, Twickenham, Saturday, 4pm, live on BBC)
15 Mike Brown (Harlequins, 23 caps)
14 Jack Nowell (Exeter Chiefs, 2 caps)
13 Luther Burrell (Northampton Saints, 2 caps)
12 Billy Twelvetrees (Gloucester Rugby, 10 caps)
11 Jonny May (Gloucester Rugby, 3 caps)
10 Owen Farrell (Saracens, 21 caps)
9 Danny Care (Harlequins, 44 caps)
1 Joe Marler (Harlequins, 17 caps)
2 Dylan Hartley (Northampton Saints, 52 caps)
3 David Wilson (Bath Rugby, 31 caps)
4 Joe Launchbury (London Wasps, 16 caps)
5 Courtney Lawes (Northampton Saints, 27 caps)
6 Tom Wood (Northampton Saints, 25 caps)
7 Chris Robshaw (Harlequins, 22 caps)(c)
8 Billy Vunipola (Saracens, 7 caps)
Replacements
16 Tom Youngs (Leicester Tigers, 14 caps)
17 Mako Vunipola (Saracens, 12 caps)
18 Henry Thomas (Sale Sharks, 3 caps)
19 Dave Attwood (Bath Rugby, 7 caps)
20 Ben Morgan (Gloucester Rugby, 17 caps)
21 Lee Dickson (Northampton Saints, 14 caps)
22 George Ford (Bath Rugby, uncapped)
23 Alex Goode (Saracens, 15 caps)
