Manz, who is included in the starting second-row for Notts, will make his first appearance of the 21/22 season after returning from injury.
Browning, Lancaster and Vanes are named among the replacements alongside former Leicester players Aniseko Sio and Ben Betts.
Fellow former Tigers included in the matchday squad are Charlie Thacker and David Williams.
Nottingham sit one place behind Ampthill on the Championship table with a game in hand on their hosts.
Elsewhere this weekend, Will Hurd is named on the Coventry Rugby bench for their Championship game against Doncaster Knights and Seb Smith included as a replacement for Loughborough Students for their match against Northumbria.