The Leicester Tigers trio have been named in the starting side for Notts with Vanes at hooker, Cusick at outside-centre and Sam Edwards at scrum-half.
Former Tigers David Williams, Aniseko Sio and Ben Betts are included in the matchday squad, as well as Nottingham-duo Scott Hall and Josh Poullet, who made their Leicester debuts during the opening round of this season's Premiership Rugby Cup.
Will Hurd is included on Coventry's bench for their trip to Ealing, with former Tiger Andy Forsyth named in the matchday squad alongside the current front-rower.
Elsewhere, Harry Simmons starts at full-back for Jersey Reds in a backline including former Tiger Jack Roberts for their away day against Ampthill.
In Spain, Joe Browning is making his England 7s debut in the HSBC World Rugby Sevens Series event.
Drawn in Pool A, England take on Fiji, Scotland and South Africa in the debut tournament for Malaga.