The Gallagher Premiership gets underway for Leicester Tigers on Saturday (September 18) afternoon at Mattioli Woods Welford Road against Exeter Chiefs.
However, elsewhere across the country and up-and-down the leagues, several members of the Tigers squad will be in action for loan clubs.
On Friday night, Nottingham Rugby welcome Ampthill to The Bay in the opening round of the Championship season and included in the Notts side are a handful of Leicester players.
Joe Browning starts on the wing, hopeful of continuing his try-scoring form from last season's Championship campaign while on loan with the Tigers partnership-club.
Named among the Nottingham replacements are Tigers youngsters are Tim Hoyt and Sam Edwards.
Former Tigers David Williams, Charlie Thacker and Ben Betts are also included in Craig Hammond's matchday squad.
On Saturday afternoon, Sam Aspland-Robinson will start on the wing for Coventry Rugby in their season-opener against Doncaster Knights.
Fellow Tigers senior squad member Dan Richardson is included on the Coventry bench alongside former Leicester back Andy Forsyth after the front-rower completed a loan move to the Championship club this week.