The Leicester Tigers centres made their Saxons debuts together against Italy A at Worcester’s Sixways Stadium on Saturday and played a big part in the 45-17 win with Tuilagi among the try-scorers.
Now Tuilagi, 19, and 22-year-old Twelvetrees have been selected to face the Wolfhounds at Ravenhill on Friday.
England Saxons head coach Stuart Lancaster said: "We were pleased with the performance given that we went into the game with only three days’ preparation, but Ireland is a significantly different challenge and there are plenty of areas we need to improve.
"We’re away from home and Ireland will be on the rebound from their defeat against Scotland A as well as looking to avenge their defeat at The Rec against us last year. So it’s about stepping up our intensity and focus this week. We’ll be going into the game with confidence but also very wary and respectful of what Ireland will bring.”
Lancaster has made three changes to his side. Prop Paul Doran-Jones (Gloucester Rugby), scrum-half Joe Simpson (London Wasps) and Nick Abendanon (Bath Rugby) come into the team for Joe Marler (Harlequins), Richard Wigglesworth (Saracens) and Mike Brown (Harlequins) respectively. Alex Corbisiero (London Irish) moves across to loosehead prop.
England Saxons to face Ireland A
15 Nick Abendanon (Bath Rugby)
14 James Simpson-Daniel (Gloucester Rugby)
13 Manu Tuilagi (Leicester Tigers)
12 Billy Twelvetrees (Leicester Tigers)
11 Ugo Monye (Harlequins)
10 Stephen Myler (Northampton Saints)
9 Joe Simpson (London Wasps)
1 Alex Corbisiero (London Irish)
2 Lee Mears (Bath Rugby)
3 Paul Doran-Jones (Gloucester Rugby)
4 Graham Kitchener (Worcester warriors)
5 Christian Day (Northampton Saints)
6 James Gaskell (Sale Sharks)
7 Chris Robshaw (Harlequins, captain)
8 Luke Narraway (Gloucester Rugby)
Replacements
16 James Buckland (London Irish)
17 Joe Marler (Harlequins)
18 George Robson (Harlequins)
19 Andrew Saull (Saracens)
20 Paul Hodgson (London Irish)
21 Brad Barritt (Saracens)
22 Mike Brown (Harlequins)
