Three Leicester Tigers players are in the England matchday squad for the final fixture of the autumn, against South Africa at Twickenham on Saturday (5.30pm).
Manu Tuilagi makes his 50th appearance for England since his debut against Wales in August 2011.
Tommy Freeman comes into the backline, Jamie George and Mako Vunipola are added to the front row and Alex Coles comes in at flanker.
The two sides last met in November 2021, where England won 27-26.
England v South Africa is live on Amazon Prime Video and talkSPORT.
15 Freddie Steward (Leicester Tigers, 16 caps)
14 Tommy Freeman (Northampton Saints, 2 caps)
13 Manu Tuilagi (Sale Sharks, 49 caps)
12 Owen Farrell (Saracens, 100 caps) (c)
11 Jonny May (Gloucester Rugby, 71 caps)
10 Marcus Smith (Harlequins, 16 caps)
9 Jack van Poortvliet (Leicester Tigers, 6 caps)
1 Mako Vunipola (Saracens, 73 caps)
2 Jamie George (Saracens, 71 caps)
3 Kyle Sinckler (Bristol Bears, 55 caps)
4 Maro Itoje (Saracens, 61 caps)
5 Jonny Hill (Sale Sharks, 18 caps)
6 Alex Coles (Northampton Saints, 2 caps)
7 Tom Curry (Sale Sharks, 44 caps)
8 Billy Vunipola (Saracens, 67 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 40 caps)
17 Ellis Genge (Bristol Bears, 42 caps)
18 Will Stuart (Bath Rugby, 24 caps)
19 David Ribbans (Northampton Saints, 2 caps)
20 Sam Simmonds (Exeter Chiefs, 17 caps)
21 Ben Youngs (Leicester Tigers, 120 caps)
22 Henry Slade (Exeter Chiefs, 51 caps)
23 Jack Nowell (Exeter Chiefs, 44 caps)