The club's Heineken Champions Cup match against Bordeaux Bègles in Round 4 of the 21/22 European season has been called off.
Bordeaux have informed EPCR that they are unable to fulfil the fixture after returning a number of positive COVID-19 results on Friday.
Leicester Tigers have been awarded a 28-0 victory and five competition points.
Speaking about the cancellation of the European fixture, Leicester Tigers Head Coach Steve Borthwick said: "First and foremost, we wish everyone at Bordeaux well and a swift recovery to those impacted.
"We are very disappointed not to be able to share a matchday with the Leicester Tigers fans at Mattioli Woods Welford Road but the safety and wellbeing of everybody must come first.
"This is another challenge for us as a group to adapt to, as we have had to at different times throughout this season, and our focus now switches to next weekend's away trip to Sale Sharks."
EPCR will confirm the club's opponents for the Round of 16 at the conclusion of this weekend's European fixtures.
TICKETS, HOSPITALITY & MATCHDAY ENQUIRIES
Leicester Tigers will communicate with season ticket holders and ticket purchasers, as well as corporate hospitality guests and group bookings purchasers later today with information following the announcement.
EPCR has been informed by Union Bordeaux-Bègles that they have a recorded a number of positive test results for Covid-19 among their tournament squad and as a consequence, the club is not in a position to fulfil its Heineken Champions Cup, Round 4 fixture against Leicester Tigers scheduled for tomorrow (Saturday 22 January).
The Pool B fixture at Mattioli Woods Welford Road is therefore regrettably cancelled with Leicester Tigers awarded the match on a 28-0, five match points basis, in accordance with the Tournament Rules.
EPCR would like to acknowledge the efforts of both clubs to fulfil the fixture, and would also like to reiterate that awarding the match to Leicester Tigers is a tournament management measure with the objective of ensuring that all fixtures in the 2021/22 Heineken Champions Cup are accounted for, and not a sanction.