Jack van Poortvliet and Ellis Genge were among the England tryscorers in a 30-28 defeat by Australia in the opening Test of the summer.
Leicester Tigers captain Genge powered over from the side of an attacking maul early in the second half as England led 11-9, but the Wallabies had added three of their own to lead by 16 points as the game entered its final minute.
Then debutants Henry Arundell and van Poortvliet, who were only on the pitch in the closing moments, both scored in the space of two minutes.
Six Leicester Tigers were named in the matchday squad, with Genge and Freddie Steward in the starting line-up and Ollie Chessum used as a second-half replacement before being joined by Joe Heyes and van Poortvliet. The uncapped Guy Porter was unused on the bench in the opening Test of the summer, played at the Optus Stadium in Perth.
England had led 6-0 on 20 minutes but scores were level at half-time, by which time Australia had lost two players to injury – after fly-half Quade Cooper withdrew in the warm-up – and then had second-rower Darcy Swain sent off after a tussle with Jonny Hill.
After conceding another three points early in the second half, Genge supplied the opening try of the game, taking ball from a maul in the right-hand corner to attack the tryline, and a Farrell penalty soon afterwards stretched the visitors' advantage to 14-9.
But the Wallabies fought back with a converted try from replacement Jordan Petaia to take a 16-14 lead with quarter of an hour to play and then saw England No8 Billy Vunipola yellow-carded for a head contact.
But the 14-man Wallabies added tries from Folau Fainga’a and Pete Samu before England’s dramatic late double.
In his senior international debut, former Under-18 and Under-20 captain Reffell played the full 80 minutes as Wales got within a few moments of an historic win before falling to a 32-29 defeat.
Wales were 18-3 in front at half-time and, after collecting three yellow cards in the closing stages as the Springboks fought back, the tourists still only had 13 on the field when Dewi Lake scored a try to level the scores at 29-29 on 76 minutes.
But with time ticking past 80 minutes, a final penalty from Damian Willemse secured a win for the hosts with Wiese collecting the man-of-the-match award on the back of his impressive performance in attack and defence.
Leicester hooker Julián Montoya led Argentina to a 26-18 win over Scotland – their first over the Scots since the 2011 World Cup – in Jujuy. Clubmate Matías Moroni was also part of the matchday squad.