Callam, one of nine senior Scotland internationals in the starting line-up, is set to make his first start of the season at Welford Road following a knee operation, though he appeared off the bench in last weekend’s narrow defeat by Toulouse.
Simon Webster is ruled out by a shin infection so John Houston, who scored against Toulouse, is handed the No.11 shirt.
Team captain Allister Hogg is at openside, Simon Cross at blindside and Ross Rennie is named among the replacements as part of the back-row rotation. The 22-year-old David Blair keeps his place at stand-off.
Tickets for the game remain on sale from the Tigers ticket office, contact 08701 28 34 30.
Edinburgh Rugby Club (v Leicester Tigers at Welford Road, Saturday, kick-off 3pm)
15 Hugo Southwell
14 Andrew Turnbull
13 Ben Cairns
12 Nick De Luca
11 John Houston
10 David Blair
9 Mike Blair
1 Allan Jacobsen
2 Ross Ford
3 Gavin Kerr
4 Craig Hamilton
5 Ben Gissing
6 Simon Cross
7 Allister Hogg (captain)
8 David Callam
Replacements
16 Andrew Kelly
17 Craig Smith
18 Matt Mustchin
19 Ross Rennie
20 Ben Meyer
21 Phil Godman
22 Andrew Maxwell
