Only Alex Moreno and Tom Varndell are called into action again following Tigers' hard-fought semi-final victory over Llanelli Scarlets in the Heineken Cup on Saturday afternoon.
Leo Cullen, who was a second-half replacement against the Scarlets, captains the side from the second row, where he is joined by fellow international James Hamilton.
James Buckland and Michael Holford link up with Moreno in the front row, while Tom Croft and Luke Abraham are selected on the flanks, with England Saxon Jordan Crane at No.8.
There's an all-Irish combination at half-back where Frank Murphy partners Ian Humphreys, while Matt Cornwell and Ollie Smith start in the centres.
Leon Lloyd and Johne Murphy join Varndell in the back three, with brothers Ben and Tom Youngs among the replacements.
Tigers vs Bristol Rugby, Tuesday, April 24, Ashton Gate (kick-off 7.45pm)
1 Alex Moreno
2 James Buckland
3 Michael Holford
4 Leo Cullen (captain)
5 James Hamilton
6 Tom Croft
7 Luke Abraham
8 Jordan Crane
9 Frank Murphy
10 Ian Humphreys
11 Tom Varndell
12 Matt Cornwell
13 Ollie Smith
14 Leon Lloyd
15 Johne Murphy
Replacements
16 Gavin Hickie
17 David Young
18 Louis Deacon
19 Brett Deacon
20 Ben Youngs
21 Tom Youngs
22 Paul Burke
