The fixture is the first of a full Six Nations programme and part of the build-up to the IRB Junior World Championships in June.
The side is coached by former England lock Nigel Redman and ex-England fly-half Mark Mapletoft, two of the RFU's National Academy coaches.
"A real positive for us is that a lot of these young players have been playing regularly in Premiership sides, in the A League and for National League clubs which has helped them make progress," Redman said.
England U20 squad
Forwards: Nathan Catt (Bath Rugby), Alex Corbisiero (London Irish), Billy Moss (Bath Rugby), Scott Freer (Leeds Carnegie), Joe Gray (Northampton Saints), Gregor Gillanders (Leicester Tigers), Scott Hobson (Cornish Pirates), Ben Thomas (Saracens), Matt Cox (Worcester Warriors), Hugo Ellis (London Wasps), Jon Fisher (London Irish), Andy Saull (Saracens)
Backs: Joe Simpson (London Wasps), Ben Youngs (Leicester Tigers), Alex Goode (Saracens), Luke Eves (Bristol Rugby), Jordan Turner-Hall (Harlequins), Miles Benjamin (Worcester Warriors), Noah Cato (Saracens), Dan Norton (Gloucester Rugby), Seb Stegmann (Harlequins), Greig Tonks (Leicester Tigers)
