Jordan Crane comes in at No8, with Martin Corry moving to the blindside flank, and Argentina’s Marcos Ayerza starting at loosehead prop.
Ayerza’s elevation to the starting XV means Tigers now include seven internationals in the pack, with a further six named in the backline.
Dan Hipkiss and Seru Rabeni continue in the centres, having both scored tries in last Saturday’s 34-24 victory at the Millennium Stadium, while Harry Ellis and Andy Goode are named at half-back, with Johne Murphy joined by Tom Varndell and Alesana Tuilagi in the back three.
England internationals George Chuter, Louis Deacon, Ben Kay, Tom Croft and Corry join Ayerza, Crane and Italian cap Martin Castrogiovanni in the forwards.
Richard Blaze returns from injury to be named in the matchday squad for the first time since December’s home fixture with Toulouse, while Ollie Smith is also named among the replacements having missed last Saturday’s win over Wasps in Cardiff.
Tigers (vs London Wasps, Welford Road, Saturday, kick-off 2.45pm)
15. Johne Murphy
14. Tom Varndell
13. Seru Rabeni
12. Dan Hipkiss
11. Alesana Tuilagi
10. Andy Goode
9. Harry Ellis
1. Marcos Ayerza
2. George Chuter
3. Martin Castrogiovanni
4. Louis Deacon
5. Ben Kay
6. Martin Corry (c)
7. Tom Croft
8. Jordan Crane
Replacements
16. Benjamin Kayser
17. Julian White
18. Richard Blaze
19. Brett Deacon
20. Christophe Lausuccq
21. Sam Vesty
22. Ollie Smith
