Southern hemisphere internationals Justin Marshall, Ben Tune and Cobus Visagie will also be involved in what is sure to be an exciting spectacle.
The Springboks celebrate 100 years of rugby tours and, fittingly, one of their original tourists will be represented by an international rugby descendant.
Full-back Thinus Delport, who played against Leicester Tigers at Welford Road earlier this month, is the great-great nephew of Anton Stegman, who was a member of the Springboks' first-ever touring team in 1906 - a tour which featured an historic match against the Midlands in Leicester.
Tickets
Tickets for the match are on sale now and are priced at £35, £30 and £20 and can be purchased through the Tigers ticket office on 08701 28 34 30 or on line at www.tigers.co.uk
World XV squad
Backs
Justin Marshall - Ospreys & New Zealand 81 caps
Gareth Cooper - Newport Gwent Dragons & Wales 32
Thomas Castaignede - Saracens & France 52
Andy Farrell - Saracens & (Great Britain / England Rugby League) 0
Ben Tune - Queensland Reds & Australia 46
Ryan Cross - Western Force & Australia Rugby League 0
Gomez Cora - Lomas Athletic (U.R.B.A) & Argentina 4
Scott Staniforth - Western Force & Australia 5
Gaffie du Toit - Free State Cheetahs & South Africa 14
Thinus Delport - Worcester Warriors & South Africa 18
Forwards
Nic Henderson - ACT Brumbies & Australia 3 caps
Dave Hewett - Edinburgh Gunners & Scotland 22
Cobus Visagie - Saracens & South Africa 29
Vernet Basualdo - Asociacion Alumni & Argentina 3
Fabio Ongaro - Saracens & Italy 44
Simon Shaw - London Wasps & England 28
Alister Campbell - ACT Brumbies & Australia 3
Michael Owen - Newport Gwent Dragons & Wales 34
David Croft - Queensland Reds & Australia 5
Jonny O'Connor - London Wasps & Ireland 12
Takuro Miuchi - NEC Rockets & Japan 30
Lawrence Dallaglio (Capt) - London Wasps & England 77
Total number of caps - 542
Coach - Bob Dwyer
Assistant coach - Bryan Redpath