Freddie Steward, Ellis Genge and Ben Youngs will all start England’s opening game of the autumn series against Tonga on Saturday.
The Leicester Tigers trio have all been selected in the matchday squad by Eddie Jones with prop Genge named alongside Tom Curry and Courtney Lawes as vice-captains for the series and Owen Farrell as captain.
Steward makes a third appearance for England and Youngs reached 110 caps, starting at scrum-half.
Head coach Jones said: “We’ve had two good preparation camps, worked really hard and we’re ready for a tough, physical game.
“We’re especially looking forward to getting back out in front of a full crowd at Twickenham and playing some entertaining, exciting rugby for all of the supporters.”
Following the Tonga fixture, England will then face Australia and world champions South Africa on successive Saturdays All matches are at Twickenham Stadium and are live on Amazon Prime Sport and TalkSPORT.
England
15 Freddie Steward (Leicester Tigers, 2 caps)
14 Adam Radwan (Newcastle Falcons, 1 cap)
13 Henry Slade (Exeter Chiefs, 40 caps)
12 Manu Tuilagi (Sale Sharks, 43 caps)
11 Jonny May (Gloucester Rugby, 66 caps)
10 Owen Farrell (Saracens, 93 caps)
9 Ben Youngs (Leicester Tigers, 109 caps)
1 Ellis Genge (Leicester Tigers, 30 caps)
2 Jamie George (Saracens, 59 caps)
3 Kyle Sinckler (Bristol Bears, 44 caps)
4 Maro Itoje (Saracens, 48 caps)
5 Jonny Hill (Exeter Chiefs, 9 caps)
6 Courtney Lawes (Northampton Saints, 87 caps)
7 Sam Underhill (Bath Rugby, 24 caps)
8 Tom Curry (Sale Sharks, 33 caps)
Finishers
16 Jamie Blamire (Newcastle Falcons, 2 caps)
17 Joe Marler (Harlequins, 72 caps)
18 Will Stuart (Bath Rugby, 12 caps)
19 Charlie Ewels (Bath Rugby, 23 caps)
20 Alex Dombrandt (Harlequins, 1 cap)
21 Alex Mitchell (Northampton Saints, uncapped)
22 Marcus Smith (Harlequins, 2 caps)
23 George Furbank (Northampton Saints, 4 caps)
Meanwhile, three more Leicester Tigers are in action elsewhere during the opening weekend of the 2021 autumn series.
Tigers back-rower Jasper Wiese has been named among the replacements for South Africa for their Test against Wales on Saturday.
Marco van Staden has not be included in the Springboks matchday squad to face the Welsh.
Argentine duo Julián Montoya and Matías Moroni have been named in the Los Pumas starting side for their game against France on Saturday.
Montoya leads the side from hooker with Moroni included at outside-centre.
